Infant girls at risk for autism pay more attention to social cues in faces than infant boys, according to new research.

OT_News-01The study, conducted by researchers with the Yale University School of Medicine, New Haven, Conn., is the first one known to prospectively examine sex-related social differences in at-risk infants, according to a news release. Findings are published in the March 2016 issue of the Journal of the American Academy of Child & Adolescent Psychiatry.

This difference in observational skills could help protect female siblings of children with autism from developing the disorder themselves, according to lead author Katarzyna Chawarska, associate professor in the Yale Child Study Center and in the pediatrics department.

For the prospective study, Chawarska and her colleagues measured spontaneous social attention in 101 infants between the ages of 6 and 12 months who have older siblings with autism. The team also studied 61 infants with no risk of autism. High-risk siblings are about 15 to 20 times more likely to have autism than those without a history of autism in the family, Chawarska said in the release.

The infants were all shown a video of a woman smiling and cooing at them, while doing other activities like pointing to toys in different parts of the screen, and preparing a sandwich. The team tracked where the infants focused their gazes, and for how long.

“We found that the girls in the high-risk group displayed more attention to people and their faces than all other infants,” said Chawarska, who also director of the Early Social Cognition Laboratory at Yale. “This increased access to social experiences during a highly formative developmental period predicted fewer social impairments at 2 years of age. It is important to note however, that this may not prevent ASD in high-risk females, but could mitigate the severity of autism symptoms.”

Chawarska’s lab now is pursuing several leads the researchers hope will help reveal the mechanisms underlying this attentional advantage in girls.

Other authors on the study include Suzanne Macari, PhD, Kelly Powell, PhD, Lauren DiNicola, BS, and Frederick Shic, PhD.

The study was funded by the National Institute of Child Health and Development, National Institutes of Mental Health and the SFARI Grant. An author on the study also received funding from the Yale Clinical and Translational Science Award grant from the National Center for Advancing Translational Sciences at the National Institutes of Health.

Study abstract: